Baclofen is centrally acting muscle relaxant known as GABAB-receptor agonist. Generic Lioresal depresses mono-and polysynaptic reflexes presumably by reducing the release of excitatory glutamate and aspartate from the terminals which occurs as a result of stimulation of presynaptic GABA-receptors.
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Determination of the optimal Lioresal INTRATHECAL dose requires individual titration. The lowest dose with an optimal response should be used. Potential need for dose adjustments in chronic use: During long term treatment, approximately 5% (28/627) of patients become refractory to increasing doses. This drug should be taken in or on a regular basis (preferably at the same time each day). If you are following a treatment with Lioresal, you must try not to miss any of your doses.
Before taking baclofen, tell your doctor if you are allergic to any drugs, or if you have kidney disease epilepsy or other seizure disorder; or a history of stroke or blood clots If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication. You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.
Sometimes - apathy, fatigue, sleep disturbances, confusion; rarely - euphoria, depression, paresthesia, myalgia, muscle weakness, ataxia, tremor, nystagmus, accommodation disturbances, hallucinations; may be more frequent seizures and lowering the threshold of their appearance. Digestive system: nausea, sometimes there are dry mouth, constipation, diarrhea, and in some cases - liver function abnormalities. Cardiovascular system: sometimes - hypotension, deterioration of the cardiovascular system.
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